Bioactive Small Molecules
Cayman Chemical ANTIBODY ETP-46464 10mg
An ATR inhibitor (IC50 = 25 nM) that also inhibits mTOR and DNA-PK (IC50s = 0.6 and 36 nM, respectively); generates replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks
Cayman Chemical ANTIBODY CAY10700 5mg
An orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay); inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively)
Medchemexpress LLC U0126-EtOH | 1173097-76-1 | MFCD25977152 | 10 mM
U0126-EtOH | Purity: 98.70% | Mol Wt: 426.56 | 1173097-76-1 | MFCD25977152 | 10 mM
Cayman Chemical 11-keto Fluprostenol 5mg
11-keto Fluprostenol is an analog of PGD2 with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor.{1182} Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.{10723}
Cayman Chemical ANTIBODY Amlexnox 500mg
An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste; associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton
Cayman Chemical ANTIBODY LH 846 10mg
A selective inhibitor of CK1δ (IC50 = 290 nM); inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein and lengthens the circadian period in U2OS cells
Cayman Chemical ANTIBODY CL 82 198 50mg
A selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 UG/ml; used to evaluate the role of MMP-13 in diverse processes
Cayman Chemical ANTIBODY AP39 10mg
A compound used to increase the levels of H2S within mitochondria; stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM; is effective in vivo
Cayman Chemical Golgcde A 5mg
A reversible inhibitor of the cis-Golgi ArfGEF, GBF1 (IC50 = 3.3 µM); induces rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network, preventing bidirectional transport of endocytic cargo
Cayman Chemical ANTIBODY ASP3026 5mg
An ALK inhibitor (IC50s = 3.5, 10, and 5.4 nM for the wild-type, ALKF1174L, and ALKR1275Q enzymes, respectively); selective for ALK over a panel of 86 kinases at 1,000 nM but also inhibits ROS1 and TNK2 (IC50s = 8.9 and 5.8 nM, respectively); inhibits the proliferation of Ba/F3 cells expressing NPM-ALK or ELM4-ALK fusion proteins (IC50s = 84 and 56 nM, respectively), as well as several crizotinib-resistant Ba/F3 cells expressing NPM-ALK or ELM4-ALK mutants; induces tumor regression in an NCI H2228 NSCLC mouse xenograft model at 10 and 30 mg/kg
Cayman Chemical ANTIBODY SpautIn-1 5mg
An autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM); promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50s = 0.58 and 0.69 µM, respectively)
Cayman Chemical ANTIBODY Amylose 5g
A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins
Cayman Chemical ProstaglndIn E2 5mg
PGE2 is one of the primary COX products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.{1585,1558,437,1330} The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.{1422} Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Cayman Chemical NtrIdecnoylLHomoserIn la 5mg
An N-acyl homoserine lactone; has been found in Y. pseudotuberculosis